Magnesium is the fourth most abundant mineral in your body. More than 3,750 magnesium-binding sites have been detected on human proteins,1 and it’s required for more than 300 different enzymes in your body.
In short, magnesium plays an important role in a wide variety of biochemical processes, including the following:
As is the case with vitamin D, if you don’t have enough magnesium, your body simply cannot function optimally, and insufficient cellular magnesium levels set the stage for deterioration of metabolic function that can snowball into more serious health problems.
For starters, magnesium is critical for the optimization of your mitochondria, which have enormous potential to influence your health, especially the prevention of cancer.
In fact, optimizing mitochondrial metabolism may be at the core of effective cancer treatment. But your mitochondrial function is also crucial for overall good health, energy, and athletic performance
Mitochondria are tiny organelles, originally thought to be derived from bacteria. Most cells have anywhere from 1 to 2,000 of them. Your organs need energy to function properly, and that energy is produced by the mitochondria in each cell.
Since mitochondrial function is at the very heart of everything that occurs in your body, optimizing mitochondrial function (and preventing mitochondrial dysfunction) by making sure you get all the right nutrients and precursors your mitochondria need is extremely important for health and disease prevention.
As explained by Rhonda Patrick, Ph.D., in the video above, magnesium plays an important role. Patrick has done extensive research on the link between mitochondrial metabolism, apoptosis and cancer, and on the effects of hyperthermic conditioning on muscle growth.
High-intensity interval training helps optimize athletic performance by increasing your oxidative capacity, meaning the ability of your muscle cells to consume oxygen. Your oxidative capacity relies on your mitochondria’s ability to produce ATP by consuming that oxygen inside the cell
As noted by Patrick, “You want your ATP production to exceed your ATP consumption, in order to enhance or maximize your performance and avoid muscle fatigue.”
You can increase your oxidative capacity in two ways:
Increasing the total number of mitochondria in your cells by engaging in high intensity interval exercises. However, in order for new mitochondria to be created, you must have sufficient amounts of magnesium.
Increasing the efficiency of your mitochondria to repair damage and produce ATP. This process also requires magnesium as a co-factor.
A century ago, we were getting an estimated 500 milligrams (mg) of magnesium from the food we ate, courtesy of the nutrient-rich soil in which it was grown. Today, estimates suggest we’re only getting 150 to 300 mg a day from our food supply.
As noted by Patrick, eating a diet rich in calories and poor in micronutrients (read processed foods) is a primary risk factor for magnesium deficiency, for the simple reason that magnesium resides at the center of the chlorophyll molecule.
Chlorophyll, as you may know, is what gives plants their green color. Most Americans eat far too few fruits and vegetables, which may explain why more than half of the American public is deficient in magnesium.
In addition to not getting sufficient amounts from your diet, magnesium is also lost through stress, lack of sleep, alcohol consumption, and prescription drug use (especially diuretics, statins, fluoride and fluoride-containing drugs such as fluoroquinolone antibiotics).
Magnesium levels can also decline in the presence of certain hormones, such as estrogen. If you have elevated insulin levels — which an estimated 80 percent of Americans do — you’re quite likely to have low magnesium levels.4
Increasing your magnesium intake may actually go a long way toward improving your condition, or warding off insulin resistance and diabetes in the first place. In one study,5 prediabetics with the highest magnesium intake reduced their risk for blood sugar and metabolic problems by 71 percent.
A second study6 also found that higher magnesium intake reduces the risk of impaired glucose and insulin metabolism and slows progression from pre-diabetes to diabetes.
According to the authors, “Magnesium intake may be particularly beneficial in offsetting your risk of developing diabetes, if you are high risk.” The mechanism by which magnesium controls glucose and insulin homeostasis appears to involve two genes responsible for magnesium homeostasis.7
Magnesium is also required to activate tyrosine kinase, an enzyme that functions as an “on” or “off” switch in many cellular functions and is required for the proper function of your insulin receptors.
Last but not least, digestive problems such as Crohn’s disease and leaky gut impair your body’s ability to absorb magnesium, which is yet another cause of inadequate magnesium levels.
As noted by Dr. Dean, it’s quite possible that magnesium insufficiency is part of why health problems such as heart disease, diabetes, and high blood pressure are so prevalent these days. It may also play a role in fibromyalgia,8 magnesium deficiency is a well-recognized factor in migraines.9
How to Identify Magnesium Deficiency
Unfortunately, there’s no lab test that will give you a truly accurate reading of your magnesium status. The reason for this is that only 1 percent of the magnesium in your body is found in your blood; 50 to 60 percent resides in your bones, and the remaining is in your soft tissues.
Since most of your magnesium is stored inside your cells and bone rather than in blood plasma, there are no satisfactory blood tests for assessing it. That said, some specialty labs do provide an RBC magnesium test which is reasonably accurate.
Other tests your doctor may use to evaluate your magnesium status include a 24-hour urine test or a sublingual epithelial test. Still, these can only give you an estimate of your levels, and doctors typically need to evaluate them in light of the symptoms you exhibit.
Early signs of magnesium deficiency may include headaches, loss of appetite, nausea and vomiting, fatigue, or weakness. More chronic magnesium deficiency can lead to far more serious symptoms such as:
Abnormal heart rhythms and coronary spasms
Muscle cramps and contractions
Numbness and tingling
These signs and symptoms are by no means an exhaustive list. In her book, “The Magnesium Miracle,” Dr. Carolyn Dean lists no less than 100 factors that will help you decide whether or not you might be deficient.
You can also follow the instructions in her blog post, “Gauging Magnesium Deficiency Symptoms,”10 which will give you a check list to go through every few weeks. This will help you gauge how much magnesium you need to resolve your deficiency symptoms.
Your Best Source of Magnesium: REAL Food
You could theoretically keep your magnesium levels in the therapeutic range without resorting to supplements simply by eating a varied diet, including plenty of dark-green leafy vegetables. One way to really increase your magnesium, as well as many other important plant-based nutrients, is by juicing your greens.
That said, it’s important to remember that the magnesium content of your foods depends on the richness of magnesium in the soil in which the plant was grown.
Most soils have become severely depleted of nutrients, and for this reason, some magnesium experts, including Dr. Dean, believe that virtually everyone needs to take supplemental magnesium.
Organic foods may have more magnesium if grown in nutrient-rich soils, but it is very difficult to make that determination. If you eat organic whole foods and have no signs of deficiency, you’re probably doing quite alright.
Suggested Dosages and Other Recommendations When Taking Magnesium Supplements
The recommended dietary allowance (RDA) for magnesium13 ranges from 310 to 420 mg per day, depending on your age and sex. However, as noted by Dr. Dean, some researchers believe we may need anywhere from 600 to 900 mg/day for optimal health.
There’s certainly many reasons for making sure you’re above the RDA, and fortunately, magnesium is quite safe so you don’t have to worry about taking too much. Dr. Dean suggests using your intestinal reaction as a marker for your ideal dose. She recommends starting out at 200 mg of oral magnesium citrate per day, and gradually increase your dose until you develop slightly loose stools.
This is your personal cutoff point, as when your body has too much magnesium it simply flushes it out the other end. Magnesium citrate is known for having a laxative effect, which is why it’s recommended in this case.
You may reach 600 mg/day before you notice a change in your bowel movements, or it may occur at a much lower dose — it depends on how much magnesium you’re getting from your diet. Keep in mind that it’s better to divide your dose and take it two or three times a day rather than taking one large dose.
Besides magnesium citrate, there are a variety of other magnesium supplements on the market. I personally prefer magnesium threonate, as it seems to penetrate cell membranes, including your mitochondria, which results in higher energy levels.
It also penetrates your blood-brain barrier and may help improve memory. The following table summarizes some of the differences between the various forms. Whichever supplement you choose, avoid those containing magnesium stearate, a common but potentially hazardous additive.